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University at Buffalo researchers have shown for the first time that melatonin-a hormone produced naturally by the pineal gland and used widely as a supplement to diminish jet lag and improve sleep patterns-may play an important role in promoting bone growth.
The study was conducted by Jerome A. Roth, PhD, professor of pharmacology and toxicology, and Moon-Il Cho, PhD, professor of oral biology. It was supported in part by a $255,000 grant from the Environ- mental Protection Agency and a $20,000 UB grant to the Periodontal Research Center; additional funding was received from the National Institute of Dental Research.
By exposing mouse pre-osteoblasts and fully differentiated rat osteoblasts-cells that produce and mineralize bone-matrix components-to melatonin, the researchers demonstrated that normal body levels of the hormone speeded up the transforma- tion of pre-osteoblasts to fully differentiated osteoblasts and induced both types of cells to produce increased amounts of several bone-matrix proteins responsible for bone formation. "After binding to its receptor on the cell surface, melatonin signals the cell to produce and mineralize bone-matrix proteins," Roth says. "This has not been shown before, and we are now investigating what cellular events are taking place to make this happen."
"We know melatonin decreases with age, and that bone loss, which can lead to osteoporosis, is an inevitable part of aging, especially among women," Cho says. "Can melatonin help prevent osteo- porosis? Our research indicates that it may have that potential."
According to Roth, human melatonin receptors are very similar to rat and mouse melatonin receptors. Under standard growth conditions in vitro, mouse pre-osteoblasts undergo cell differentiation to osteoblasts and mineralization in 21 days. Roth and Cho showed that in the presence of melatonin, cell differentiation was completed by day 12 and was equivalent or greater at that point than cells grown for 21 days. Most significantly, says Roth, further experiments showed that the mouse pre- osteoblasts responded to normal body levels of melatonin, but the cells needed to under-go five to seven days of differentiation before they were capable of responding to melatonin at that level.
"These findings place melatonin with a select handful of other agents that are known to stimulate mineralization in osteoblasts," says Roth. "Because melatonin levels decrease during the aging process, the possibility must be considered that melatonin may have a significant influence on the rate of synthesis and maintenance of bone in the elderly." About GROWTH BOOSTER PLUS - How You Too Can Grow Taller And Sleep Better Too!
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