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New Osteoporosis Drug Spurs Bone Growth
Reviewed By Brunilda Nazario, MD on Wednesday, November 27, 2002
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Nov. 27, -- The FDA has approved the first drug for osteoporosis that has been shown to actually stimulate bone growth. Forteo (teriparatide) is the first in a new class of drugs called bone formation agents that promotes bone growth by increasing the activity and number of bone-forming cells called osteoblasts. Forteo is derived from the parathyroid hormone, which is the primary regulator of calcium in bone.
Until now, drugs approved to treat osteoporosis have worked to slow or stop bone loss by targeting bone-weakening cells called osteoclasts, but they do not prompt new bone growth.
Osteoporosis occurs when these osteoclasts begin to remove bone faster than it can be replaced by the osteoblasts and leads to a progressive thinning of the bones. About 10 million Americans, 80% of them women, suffer from the condition and are at increased risk of bone fractures in the spine, wrist, and hip.
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