Subsequent to its discovery, the endogenous arterial vasodilator “endothelium-derived relaxing factor” (EDRF) was determined to be chemically identical to the free radical gas nitric oxide (NO). Known to be present in macrophages, NO is thought to mediate a number of macrophage cytotoxic actions. Endogenous NO is believed to mediate many diverse physiological processes including vasorelaxation, immune responses, adhesion of leukocytes and platelets, and neurotransmission. NO is not the same as nitrous oxide (N2O), the general anesthetic known as “laughing gas.” The basic amino acid L-arginine is the precursor for the synthesis of NO in mammals.
As it can be synthesized endogenously from L-citrulline, L-arginine is classified as a non-essential amino acid in adults. However, in children and in conditions of accelerated growth as seen following trauma or infection, L-arginine synthesis may become inadequate. Thus, L-arginine may be considered “semi-essential” in certain situations. In addition to occurring in the liver, much of the endogenous synthesis of L-arginine from L-citrulline takes place in the proximal tubule of the kidney during the formation of urea.
L-Arginine, which constitutes approximately 5% of the amino acid content of the typical adult diet, is absorbed in the lower 2/3 of the small intestine along with other basic amino acids. Absorption involves uptake by the gastrointestinal enterocytes, where about 60% of the L-arginine is metabolized, and only 40% reaches the systemic circulation intact. Although some protein-containing foods may have slightly higher L-arginine contents than others, nutritionally there is little difference between most proteins with respect to this amino acid. Thus, as described in this article, the only way to effectively deliver more L-arginine to the individual would be to supplement with the amino acid itself.
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As it can be synthesized endogenously from L-citrulline, L-arginine is classified as a non-essential amino acid in adults. However, in children and in conditions of accelerated growth as seen following trauma or infection, L-arginine synthesis may become inadequate. Thus, L-arginine may be considered “semi-essential” in certain situations. In addition to occurring in the liver, much of the endogenous synthesis of L-arginine from L-citrulline takes place in the proximal tubule of the kidney during the formation of urea.
L-Arginine, which constitutes approximately 5% of the amino acid content of the typical adult diet, is absorbed in the lower 2/3 of the small intestine along with other basic amino acids. Absorption involves uptake by the gastrointestinal enterocytes, where about 60% of the L-arginine is metabolized, and only 40% reaches the systemic circulation intact. Although some protein-containing foods may have slightly higher L-arginine contents than others, nutritionally there is little difference between most proteins with respect to this amino acid. Thus, as described in this article, the only way to effectively deliver more L-arginine to the individual would be to supplement with the amino acid itself.
"The Grow Taller Guys"
Learn how these PURE EXTRACTED NUTRIENTS TO GROW TALLER has helped many grow taller and faster.